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Atypical antidepressants

Atypical antidepressants approved by the FDA

The Food and Drug Administration (FDA) approved these atypical antidepressants to treat depression:

  • Bupropion (Wellbutrin SR, Wellbutrin XL, others)
  • Mirtazapine (Remeron)
  • Nefazodone
  • Trazodone
  • Vilazodone (Viibryd)
  • Vortioxetine (Trintellix)

A new antidepressant called esketamine (Spravato) is FDA approved for treatment-resistant depression. It's a nasal spray intended for use in combination with an oral antidepressant.