Imipramine

How it works

Imipramine is a tricyclic antidepressant. It makes the bladder muscle relax, while causing the smooth muscles at the bladder neck to contract. It may be used to treat mixed incontinence, which is a combination of urge and stress incontinence.

Imipramine can cause drowsiness, so it's often taken at night. Because of this, imipramine may be useful for nighttime incontinence. It may also be helpful for children who bed-wet at night. Imipramine isn't usually a good fit for older adults.

Side effects

Serious side effects from imipramine are rare but can include heart and blood vessel problems. They may include an irregular heartbeat and dizziness or fainting from low blood pressure when you stand up quickly. Children and older adults may be especially at risk of these side effects.

Other side effects may include dry mouth, blurry vision and constipation. Tricyclic antidepressants interact with other drugs. Make sure your healthcare professional knows all the medicines you're taking.