Sleep problems

Difficulty falling or staying asleep (insomnia) may be a result of mood problems caused by peginterferon alfa, potentially worsening depression and anxiety. Insomnia is also a side effect of ribavirin, as well as of the new combination treatment of ledipasvir-sofosbuvir (Harvoni). To get enough sleep:

• If you're also being treated for depression, take an antidepressant that improves sleep rather than one that makes you alert
• Stick to a regular schedule of going to bed at night and getting up in the morning
• Avoid reading and watching TV in bed
• Take ribavirin in the late afternoon
• Avoid caffeine
• Try not to nap during the day
• Eat a light meal well before bedtime
• Limit the fluid you drink in the two hours before bedtime, so you won't have to go to the bathroom during the night
• Wind down with a recorded relaxation exercise, warm bath or massage before going to bed
• Take a sleep-promoting medication under your doctor's supervision