Interactions

Possible interactions include:

• Anticonvulsants. Taking folic acid with fosphenytoin (Cerebyx), phenytoin (Dilantin, Phenytek) or primidone (Mysoline) might decrease the drug's concentration in your blood.
• Barbiturates. Taking folic acid with a drug that acts as a central nervous system depressant (barbiturate) might decrease the drug's effectiveness.
• Methotrexate (Trexall). Taking folic acid with this medication used to treat cancer could interfere with its effectiveness.
• Pyrimethamine (Daraprim). Taking folic acid with this antimalarial drug might reduce the effectiveness of the drug.