Medications can boost or lower HDL

HDL levels are sometimes improved by drugs used to lower LDL and triglyceride levels — such as prescription niacin; fibrates such as gemfibrozil (Lopid); and certain statins, particularly simvastatin (Zocor) and rosuvastatin (Crestor).

But clinical trials for several drugs specifically designed to increase HDL levels were halted early, because they didn't reduce the risk of heart attacks.

Drugs containing testosterone and other anabolic steroids can artificially lower your HDL cholesterol levels. Avoiding these drugs may help increase your HDL numbers.