Interactions

Use of some drugs can affect your vitamin E levels. Possible interactions include:

• Alkylating agents and anti-tumor antibiotics. There's concern that high doses of vitamin E might affect the use of these chemotherapy drugs.
• Anticoagulants and anti-platelet drugs, herbs and supplements. Use of vitamin E with these drugs, herbs and supplements to reduce blood clotting might increase the risk of bleeding.
• Cytochrome P450 3A4 (CYP3A4) substrates. Use caution when taking vitamin E and other drugs affected by these enzymes, such as omeprazole (Prilosec, Zegerid).
• Statins and niacin. Taking vitamin E with statins or niacin, which might benefit people with high cholesterol, could reduce niacin's effect.
• Vitamin K. Taking vitamin E with vitamin K might decrease the effects of vitamin K.