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Warfarin side effects: Watch for interactions

What drugs and supplements can interact with warfarin?

Like any other medication, warfarin can interact with foods, other drugs, vitamins or herbal supplements. The interaction might lower the effectiveness of warfarin or increase your risk of bleeding. More than 120 drugs and foods that can interact with warfarin have been identified.

Drugs that can interact with warfarin include:

  • Many antibiotics
  • Antifungal medications, such as fluconazole (Diflucan)
  • Aspirin or aspirin-containing products
  • Ibuprofen (Advil, Motrin IB, others) or naproxen sodium (Aleve, Anaprox)
  • Acetaminophen (Tylenol, others) or acetaminophen-containing products
  • Cold or allergy medicines
  • Medications that treat abnormal heart rhythms, such as amiodarone (Amiodarone HCl, Pacerone)
  • Antacids or laxatives

Many other medications interact with warfarin. Be sure to tell your doctor or pharmacist that you take warfarin.

Supplements that can interact with warfarin include:

  • Coenzyme Q10 (Ubiquinone)
  • Dong quai
  • Garlic
  • Ginkgo biloba
  • Ginseng
  • Green tea
  • St. John's wort
  • Vitamin E

Many other supplements can interact with warfarin. Be sure to tell your health care provider about any supplements you take.