Symptoms

You may not experience signs and symptoms of amyloidosis until the condition is advanced. When signs and symptoms are evident, they depend on which of your organs are affected.

Signs and symptoms of amyloidosis may include:

• Swelling of your ankles and legs
• Severe fatigue and weakness
• Shortness of breath with minimal exertion
• Unable to lie flat in bed due to shortness of breath
• Numbness, tingling or pain in your hands or feet, especially pain in your wrist (carpal tunnel syndrome)
• Diarrhea, possibly with blood, or constipation
• Unintentional weight loss of more than 10 pounds (4.5 kilograms)
• An enlarged tongue, which sometimes looks rippled around its edge
• Skin changes, such as thickening or easy bruising, and purplish patches around the eyes
• An irregular heartbeat
• Difficulty swallowing

When to see a doctor

See your doctor if you persistently experience any of the signs or symptoms associated with amyloidosis.