Causes

C. difficile bacteria enter the body through the mouth. They can begin reproducing in the small intestine. When they reach the large intestine (colon), they can release tissue-damaging toxins. These toxins destroy cells, produce patches of inflammatory cells and cellular debris, and cause watery diarrhea.

When the bacteria are outside the colon — virtually anywhere in the environment — they are in a dormant state, or essentially shutdown. This enables them to survive for a long time in any number of places:

• Human or animal feces
• Surfaces in a room
• Unwashed hands
• Soil
• Water
• Food, including meat

When bacteria once again find their way into a person's digestive system, they "wake up" and can begin to produce infection again. The ability of dormant C. difficile to survive outside the body enables the generally easy transmission of the bacterium, particularly in the absence of thorough hand-washing and cleaning.