Diseases and Conditions

Cryoglobulinemia

Symptoms

Symptoms usually come and go, and may include:

  • Skin lesions. Most people with cryoglobulinemia develop purplish skin lesions on their legs. In some people, leg ulcers also occur.
  • Joint pain. Symptoms resembling rheumatoid arthritis are common in cryoglobulinemia.
  • Peripheral neuropathy. Cryoglobulinemia can damage the nerves at the tips of your fingers and toes, causing numbness and other problems.