Lifestyle and home remedies

Other ways to control symptoms of mixed connective tissue disease include:

• Nonsteroidal anti-inflammatory drugs. These medications, such as ibuprofen (Advil, Motrin IB, others) or naproxen sodium (Aleve), might help relieve the pain and inflammation if your condition is mild.
• Protecting hands from cold. Wearing gloves and taking other measures to keep your hands warm can help prevent Raynaud's phenomenon.
• Not smoking. Smoking causes blood vessels to narrow, which can worsen the effects of Raynaud's phenomenon.
• Reducing stress. Raynaud's phenomenon is often triggered by stress. Relaxation techniques — such as slowing and focusing on your breathing — can help reduce your stress levels.