Symptoms

Myelofibrosis usually develops slowly. In its very early stages, many people don't experience signs or symptoms.

As disruption of normal blood cell production increases, signs and symptoms may include:

• Feeling tired, weak or short of breath, usually because of anemia
• Pain or fullness below your ribs on the left side, due to an enlarged spleen
• Easy bruising
• Easy bleeding
• Excessive sweating during sleep (night sweats)
• Fever
• Bone pain

When to see a doctor

Make an appointment with your doctor if you have any persistent signs and symptoms that worry you.