Diseases and Conditions

Ovarian cancer

Risk factors

Factors that can increase your risk of ovarian cancer include:

  • Older age. The risk of ovarian cancer increases as you age. It's most often diagnosed in older adults.
  • Inherited gene changes. A small percentage of ovarian cancers are caused by genes changes you inherit from your parents. The genes that increase the risk of ovarian cancer include BRCA1 and BRCA2. These genes also increase the risk of breast cancer.

    Several other gene changes are known to increase the risk of ovarian cancer, including gene changes associated with Lynch syndrome and the genes BRIP1, RAD51C and RAD51D.

  • Family history of ovarian cancer. If you have blood relatives who have been diagnosed with ovarian cancer, you may have an increased risk of the disease.
  • Being overweight or obese. Being overweight or obese increases the risk of ovarian cancer.
  • Postmenopausal hormone replacement therapy. Taking hormone replacement therapy to control menopause signs and symptoms may increase the risk of ovarian cancer.
  • Endometriosis. Endometriosis is an often painful disorder in which tissue similar to the tissue that lines the inside of your uterus grows outside your uterus.
  • Age when menstruation started and ended. Beginning menstruation at an early age or starting menopause at a later age, or both, may increase the risk of ovarian cancer.
  • Never having been pregnant. If you've never been pregnant, you may have an increased risk of ovarian cancer.