Diagnosis

To diagnose what might be causing your swollen lymph nodes, your doctor may need:

• Your medical history. Your doctor will want to know when and how your swollen lymph nodes developed and if you have any other signs or symptoms.
• A physical exam. Your doctor will also want to check lymph nodes near the surface of your skin for size, tenderness, warmth and texture. The site of your swollen lymph nodes and your other signs and symptoms will offer clues to the underlying cause.
• Blood tests. Certain blood tests may help confirm or exclude any suspected underlying conditions. The specific tests will depend on the suspected cause, but most likely will include a complete blood count (CBC). This test helps evaluate your overall health and detect a range of disorders, including infections and leukemia.
• Imaging studies. A chest X-ray or computerized tomography (CT) scan of the affected area may help determine potential sources of infection or find tumors.
• Lymph node biopsy. Your doctor may have you undergo a biopsy to secure the diagnosis. He or she will remove a sample from a lymph node or even an entire lymph node for microscopic examination.