Symptoms

Signs and symptoms of systemic mastocytosis depend on the part of the body affected by excessive mast cells. Too many mast cells can build up in the skin, liver, spleen, bone marrow or intestines. Less commonly, other organs such as the brain, heart or lungs also may be affected.

Signs and symptoms of systemic mastocytosis may include:

• Flushing, itching or hives
• Abdominal pain, diarrhea, nausea or vomiting
• Anemia or bleeding disorders
• Bone and muscle pain
• Enlarged liver, spleen or lymph nodes
• Depression, mood changes or problems concentrating

The mast cells are triggered to produce substances that cause inflammation and symptoms. People have different triggers, but the most common ones include:

• Alcohol
• Skin irritation
• Spicy foods
• Exercise
• Insect stings
• Certain medications

When to see a doctor

Talk to your doctor if you have problems with flushing or hives, or if you have concerns about the signs or symptoms listed above.