Symptoms

Signs and symptoms of Zollinger-Ellison syndrome may include:

• Abdominal pain
• Diarrhea
• Burning, aching, gnawing or discomfort in your upper abdomen
• Acid reflux and heartburn
• Burping
• Nausea and vomiting
• Bleeding in your digestive tract
• Unintended weight loss
• Decreased appetite

When to see a doctor

See your doctor if you have a persistent, burning, aching or gnawing pain in your upper abdomen, especially if you've also been experiencing nausea, vomiting and diarrhea.

Tell your doctor if you've used over-the-counter acid-reducing medications such as omeprazole (Prilosec, Zegerid), cimetidine (Tagamet HB) or famotidine (Pepcid AC) for long periods of time. These medications may mask your symptoms, which could delay your diagnosis.