Evidence

Research on SAMe use for specific conditions shows:

• Depression. While research has shown that SAMe has a positive effect in treating depression, most studies weren't well designed and included a small number of people.
• Liver disease. More studies are needed to determine whether SAMe is beneficial for people who have liver disease.
• Osteoarthritis. Many studies comparing the use of SAMe with nonsteroidal anti-inflammatory drugs showed that each provided similar pain relief and improvement in joint function, but SAMe produced fewer side effects. A smaller number of studies haven't shown the same results.