Interactions

Possible interactions include:

• Antidepressants and other drugs and supplements that increase levels of serotonin. Don't take SAMe with antidepressants. The combination could cause effects similar to a condition caused by high levels of the chemical serotonin to accumulate in your body (serotonin syndrome).
• Antipsychotics. Be cautious when taking these drugs with SAMe. The combination could increase the risk of serotonin syndrome.
• Amphetamines. Be cautious when taking these drugs with SAMe. The combination could increase the risk of serotonin syndrome.
• Dextromethorphan. Taking SAMe with this cough suppressant could increase the risk of serotonin syndrome.
• Levodopa. SAMe might reduce the effectiveness of levodopa (Inbrija), a medication used to treat Parkinson's disease.
• Narcotics. Taking SAMe with meperidine (Demerol) or tramadol (Ultram, ConZip) could increase the risk of serotonin syndrome.
• St. John's wort. Be cautious when taking this supplement with SAMe. The combination could cause serotonin syndrome.