Overview

S-adenosyl-L-methionine (SAMe) is a compound found naturally in the body. SAMe helps produce and regulate hormones and maintain cell membranes.

A synthetic version of SAMe is available as a dietary supplement in the U.S. In some countries in Europe, SAMe is a prescription drug.

SAMe can be taken orally, through a muscular injection or by IV. People generally use SAMe to treat depression, osteoarthritis and liver disease. However, SAMe can also interact with antidepressant medications.